EGFR mutation frequency in Middle East and African non-small cell lung cancer patients: a systematic review and meta-analysis
Identifieur interne : 000488 ( Main/Exploration ); précédent : 000487; suivant : 000489EGFR mutation frequency in Middle East and African non-small cell lung cancer patients: a systematic review and meta-analysis
Auteurs : Zineb Benbrahim [Maroc] ; Teresita Antonia ; Nawfel Mellas [Maroc]Source :
- BMC Cancer [ 1471-2407 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : ErbB Receptors.
- genetics : Asian Continental Ancestry Group, Carcinoma, Non-Small-Cell Lung, European Continental Ancestry Group.
- Africa, Female, Humans, Male, Middle East, Mutation, Mutation Rate.
Abstract
Our goal was to investigate the prevalence of the epidermal growth factor receptor (EGFR) mutation in Middle East and African countries and to compare its prevalence with that shown in other populations.
We used PubMed and the Cochrane Library databases to conduct a literature search using the terms “[EGFR] AND [mutation] AND [Non Small Cell Lung Cancer] AND [Middle East OR Africa].” We assessed studies published in English and French from 2004 until 2016.
Ten relevant studies were included in this systematic review. Overall, 1215 patients with non-small cell lung cancer (NSCLC) were included in this analysis. The overall ratio of male to female patients was 2.15. Of total patients included, 41.1% had never smoked and 85.8% had been diagnosed with adenocarcinoma. In 8 of the 10 studies, polymerase chain reaction (PCR) analyses were conducted to identify EGFR mutations. In total, 257 patients had an
The EGFR mutation frequency in Middle East and African patients is higher than that shown in white populations but still lower than the frequency reported in Asian populations.
Url:
DOI: 10.1186/s12885-018-4774-y
PubMed: 30217176
PubMed Central: 6137870
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000032
- to stream Pmc, to step Curation: 000032
- to stream Pmc, to step Checkpoint: 000161
- to stream PubMed, to step Corpus: 000323
- to stream PubMed, to step Curation: 000322
- to stream PubMed, to step Checkpoint: 000360
- to stream Main, to step Merge: 000488
- to stream Main, to step Curation: 000488
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">EGFR mutation frequency in Middle East and African non-small cell lung cancer patients: a systematic review and meta-analysis</title><author><name sortKey="Benbrahim, Zineb" sort="Benbrahim, Zineb" uniqKey="Benbrahim Z" first="Zineb" last="Benbrahim">Zineb Benbrahim</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2337 1523</institution-id><institution-id institution-id-type="GRID">grid.20715.31</institution-id><institution>Department of Medical Oncology, Hassan II University Hospital, Faculty of Medicine and Pharmacy of Fez,</institution><institution>University Sidi Mohammed Ben Abdellah,</institution></institution-wrap>Fez, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Fez</wicri:regionArea></affiliation></author><author><name sortKey="Antonia, Teresita" sort="Antonia, Teresita" uniqKey="Antonia T" first="Teresita" last="Antonia">Teresita Antonia</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9891 5233</institution-id><institution-id institution-id-type="GRID">grid.468198.a</institution-id><institution>H. Lee Moffitt Cancer Center and Research Institute,</institution></institution-wrap>Tampa, Florida USA</nlm:aff><wicri:noCountry code="subfield">Florida USA</wicri:noCountry></affiliation></author><author><name sortKey="Mellas, Nawfel" sort="Mellas, Nawfel" uniqKey="Mellas N" first="Nawfel" last="Mellas">Nawfel Mellas</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2337 1523</institution-id><institution-id institution-id-type="GRID">grid.20715.31</institution-id><institution>Department of Medical Oncology, Hassan II University Hospital, Faculty of Medicine and Pharmacy of Fez,</institution><institution>University Sidi Mohammed Ben Abdellah,</institution></institution-wrap>Fez, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Fez</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30217176</idno><idno type="pmc">6137870</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137870</idno><idno type="RBID">PMC:6137870</idno><idno type="doi">10.1186/s12885-018-4774-y</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000032</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000032</idno><idno type="wicri:Area/Pmc/Curation">000032</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000032</idno><idno type="wicri:Area/Pmc/Checkpoint">000161</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000161</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:30217176</idno><idno type="wicri:Area/PubMed/Corpus">000323</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000323</idno><idno type="wicri:Area/PubMed/Curation">000322</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000322</idno><idno type="wicri:Area/PubMed/Checkpoint">000360</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000360</idno><idno type="wicri:Area/Main/Merge">000488</idno><idno type="wicri:Area/Main/Curation">000488</idno><idno type="wicri:Area/Main/Exploration">000488</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">EGFR mutation frequency in Middle East and African non-small cell lung cancer patients: a systematic review and meta-analysis</title><author><name sortKey="Benbrahim, Zineb" sort="Benbrahim, Zineb" uniqKey="Benbrahim Z" first="Zineb" last="Benbrahim">Zineb Benbrahim</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2337 1523</institution-id><institution-id institution-id-type="GRID">grid.20715.31</institution-id><institution>Department of Medical Oncology, Hassan II University Hospital, Faculty of Medicine and Pharmacy of Fez,</institution><institution>University Sidi Mohammed Ben Abdellah,</institution></institution-wrap>Fez, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Fez</wicri:regionArea></affiliation></author><author><name sortKey="Antonia, Teresita" sort="Antonia, Teresita" uniqKey="Antonia T" first="Teresita" last="Antonia">Teresita Antonia</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9891 5233</institution-id><institution-id institution-id-type="GRID">grid.468198.a</institution-id><institution>H. Lee Moffitt Cancer Center and Research Institute,</institution></institution-wrap>Tampa, Florida USA</nlm:aff><wicri:noCountry code="subfield">Florida USA</wicri:noCountry></affiliation></author><author><name sortKey="Mellas, Nawfel" sort="Mellas, Nawfel" uniqKey="Mellas N" first="Nawfel" last="Mellas">Nawfel Mellas</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2337 1523</institution-id><institution-id institution-id-type="GRID">grid.20715.31</institution-id><institution>Department of Medical Oncology, Hassan II University Hospital, Faculty of Medicine and Pharmacy of Fez,</institution><institution>University Sidi Mohammed Ben Abdellah,</institution></institution-wrap>Fez, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Fez</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMC Cancer</title><idno type="eISSN">1471-2407</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa (MeSH)</term><term>Asian Continental Ancestry Group (genetics)</term><term>Carcinoma, Non-Small-Cell Lung (genetics)</term><term>ErbB Receptors (genetics)</term><term>European Continental Ancestry Group (genetics)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle East (MeSH)</term><term>Mutation (MeSH)</term><term>Mutation Rate (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Afrique (MeSH)</term><term>Carcinome pulmonaire non à petites cellules (génétique)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Moyen Orient (MeSH)</term><term>Mutation (MeSH)</term><term>Mâle (MeSH)</term><term>Population d'origine asiatique (génétique)</term><term>Population d'origine européenne (génétique)</term><term>Récepteurs ErbB (génétique)</term><term>Taux de mutation (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>ErbB Receptors</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asian Continental Ancestry Group</term><term>Carcinoma, Non-Small-Cell Lung</term><term>European Continental Ancestry Group</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Population d'origine asiatique</term><term>Population d'origine européenne</term><term>Récepteurs ErbB</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Africa</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle East</term><term>Mutation</term><term>Mutation Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Afrique</term><term>Femelle</term><term>Humains</term><term>Moyen Orient</term><term>Mutation</term><term>Mâle</term><term>Taux de mutation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Our goal was to investigate the prevalence of the epidermal growth factor receptor (EGFR) mutation in Middle East and African countries and to compare its prevalence with that shown in other populations.</p></sec><sec><title>Methods</title><p id="Par2">We used PubMed and the Cochrane Library databases to conduct a literature search using the terms “[EGFR] AND [mutation] AND [Non Small Cell Lung Cancer] AND [Middle East OR Africa].” We assessed studies published in English and French from 2004 until 2016.</p></sec><sec><title>Results</title><p id="Par3">Ten relevant studies were included in this systematic review. Overall, 1215 patients with non-small cell lung cancer (NSCLC) were included in this analysis. The overall ratio of male to female patients was 2.15. Of total patients included, 41.1% had never smoked and 85.8% had been diagnosed with adenocarcinoma. In 8 of the 10 studies, polymerase chain reaction (PCR) analyses were conducted to identify EGFR mutations. In total, 257 patients had an <italic>EGFR</italic> mutation, corresponding to a prevalence of 21.2%. The most frequent abnormality detected in all of the studies was in exon 19. In addition, all studies concluded the presence of a correlation between EGFR mutation status and female sex, non-smoking status, and adenocarcinoma subtype.</p></sec><sec><title>Conclusions</title><p id="Par4">The EGFR mutation frequency in Middle East and African patients is higher than that shown in white populations but still lower than the frequency reported in Asian populations.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author><author><name sortKey="Siegel, R" uniqKey="Siegel R">R Siegel</name></author><author><name sortKey="Ward, E" uniqKey="Ward E">E Ward</name></author><author><name sortKey="Murray, T" uniqKey="Murray T">T Murray</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Thun, Mj" uniqKey="Thun M">MJ Thun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molina, Jr" uniqKey="Molina J">JR Molina</name></author><author><name sortKey="Yang, P" uniqKey="Yang P">P Yang</name></author><author><name sortKey="Cassivi, Sd" uniqKey="Cassivi S">SD Cassivi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sequist, Lv" uniqKey="Sequist L">LV Sequist</name></author><author><name sortKey="Joshi, Va" uniqKey="Joshi V">VA Joshi</name></author><author><name sortKey="Janine, Pa" uniqKey="Janine P">PA Janine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, Sv" uniqKey="Sharma S">SV Sharma</name></author><author><name sortKey="Bell, Dw" uniqKey="Bell D">DW Bell</name></author><author><name sortKey="Settleman, J" uniqKey="Settleman J">J Settleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kota, R" uniqKey="Kota R">R Kota</name></author><author><name sortKey="Gundeti, S" uniqKey="Gundeti S">S Gundeti</name></author><author><name sortKey="Gullipalli, M" uniqKey="Gullipalli M">M Gullipalli</name></author><author><name sortKey="Linga, V" uniqKey="Linga V">V Linga</name></author><author><name sortKey="Maddali, Ls" uniqKey="Maddali L">LS Maddali</name></author><author><name sortKey="Digumarti, R" uniqKey="Digumarti R">R Digumarti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, Z" uniqKey="Wei Z">Z Wei</name></author><author><name sortKey="Christiani, Dc" uniqKey="Christiani D">DC Christiani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Midha, A" uniqKey="Midha A">A Midha</name></author><author><name sortKey="Dearden, S" uniqKey="Dearden S">S Dearden</name></author><author><name sortKey="Mccormack, R" uniqKey="Mccormack R">R McCormack</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Naderi, S" uniqKey="Naderi S">S Naderi</name></author><author><name sortKey="Ghorra, C" uniqKey="Ghorra C">C Ghorra</name></author><author><name sortKey="Haddad, F" uniqKey="Haddad F">F Haddad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fakhruddin, N" uniqKey="Fakhruddin N">N Fakhruddin</name></author><author><name sortKey="Mahfouz, R" uniqKey="Mahfouz R">R Mahfouz</name></author><author><name sortKey="Farhat, F" uniqKey="Farhat F">F Farhat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kattan, Jg" uniqKey="Kattan J">JG Kattan</name></author><author><name sortKey="Haddad, F" uniqKey="Haddad F">F Haddad</name></author><author><name sortKey="Kourie, Hr" uniqKey="Kourie H">HR Kourie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Ma" uniqKey="Zaki M">MA Zaki</name></author><author><name sortKey="Ramadan, Ra" uniqKey="Ramadan R">RA Ramadan</name></author><author><name sortKey="Mahmoud, Mi" uniqKey="Mahmoud M">MI Mahmoud</name></author><author><name sortKey="El Kaffash, Dm" uniqKey="El Kaffash D">DM El-Kaffash</name></author><author><name sortKey="Assaad, Rs" uniqKey="Assaad R">RS Assaad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Unal, Ou" uniqKey="Unal O">OU Unal</name></author><author><name sortKey="Oztop, I" uniqKey="Oztop I">I Oztop</name></author><author><name sortKey="Calibasi, G" uniqKey="Calibasi G">G Calibasi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bircan, S" uniqKey="Bircan S">S Bircan</name></author><author><name sortKey="Baloglu, H" uniqKey="Baloglu H">H Baloglu</name></author><author><name sortKey="Kucukodaci, Z" uniqKey="Kucukodaci Z">Z Kucukodaci</name></author><author><name sortKey="Bircan, A" uniqKey="Bircan A">A Bircan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Kuraya, K" uniqKey="Al Kuraya K">K Al-Kuraya</name></author><author><name sortKey="Siraj, Ak" uniqKey="Siraj A">AK Siraj</name></author><author><name sortKey="Bavi, P" uniqKey="Bavi P">P Bavi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jazieh, Ar" uniqKey="Jazieh A">AR Jazieh</name></author><author><name sortKey="Jaafar, H" uniqKey="Jaafar H">H Jaafar</name></author><author><name sortKey="Jaloudi, M" uniqKey="Jaloudi M">M Jaloudi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jazieh, Ar" uniqKey="Jazieh A">AR Jazieh</name></author><author><name sortKey="Jaafar, Hn" uniqKey="Jaafar H">HN Jaafar</name></author><author><name sortKey="Mustafa, R" uniqKey="Mustafa R">R Mustafa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Errihani, H" uniqKey="Errihani H">H Errihani</name></author><author><name sortKey="Inrhaoun, H" uniqKey="Inrhaoun H">H Inrhaoun</name></author><author><name sortKey="Boukir, A" uniqKey="Boukir A">A Boukir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mitsudomi, T" uniqKey="Mitsudomi T">T Mitsudomi</name></author><author><name sortKey="Yatabe, Y" uniqKey="Yatabe Y">Y Yatabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salim, Ei" uniqKey="Salim E">EI Salim</name></author><author><name sortKey="Jazieh, Ar" uniqKey="Jazieh A">AR Jazieh</name></author><author><name sortKey="Moore, Ma" uniqKey="Moore M">MA Moore</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Maroc</li></country></list><tree><noCountry><name sortKey="Antonia, Teresita" sort="Antonia, Teresita" uniqKey="Antonia T" first="Teresita" last="Antonia">Teresita Antonia</name></noCountry><country name="Maroc"><noRegion><name sortKey="Benbrahim, Zineb" sort="Benbrahim, Zineb" uniqKey="Benbrahim Z" first="Zineb" last="Benbrahim">Zineb Benbrahim</name></noRegion><name sortKey="Mellas, Nawfel" sort="Mellas, Nawfel" uniqKey="Mellas N" first="Nawfel" last="Mellas">Nawfel Mellas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/MaghrebDataLibMedV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000488 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000488 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= MaghrebDataLibMedV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6137870
|texte= EGFR mutation frequency in Middle East and African non-small cell lung cancer patients: a systematic review and meta-analysis
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30217176" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MaghrebDataLibMedV2
| This area was generated with Dilib version V0.6.38. |  |